Drug profile

The FDA adverse-event record for Isoflupredone

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Isoflupredone. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
42.9%
death-coded share
Cattle
most-reported species
11
Anaphylaxis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
9
Deaths Reported
42.9%
Death Rate

Active Ingredients

Isoflupredone

Administration Routes

IntramuscularUnknownIntra-ArticularTopical

Species Affected

Cattle 14
Unknown 4
Horse 2
Human 1

Most Affected Breeds

Holstein-Friesian also known as Holstein 8
Unknown 5
Cattle (unknown) 2
Quarter Horse 2
Crossbred Bovine/Cattle 1
Jersey 1
Aberdeen Angus 1
Brown Swiss 1

Most Reported Reactions

Anaphylaxis 11
Death 9
Vaginal swelling 7
Eyelid oedema 5
Collapse (see also 'Cardio-vascular' and 'Systemic disorders') 3
Dyspnoea 3
Hypersalivation 3
Lung oedema 2
Mammary gland disorder NOS 2
PR-LUNG(S), LESION(S) 2
Tachypnoea 2
Skin lesion NOS 2

Outcome Breakdown

Died
9 (100.0%)

Isoflupredone Adverse Event Insights

21 reports name Isoflupredone; 9 recorded a death outcome (42.9% of reported events, not a population-level mortality rate). Active ingredient: Isoflupredone. Administration routes: Intramuscular, Unknown, Intra-Articular, Topical.

By species: Cattle (14 reports), Unknown (4 reports), Horse (2 reports). By breed: Holstein-Friesian also known as Holstein (8), Unknown (5), Cattle (unknown) (2).

Leading clinical signs: Anaphylaxis (11), Death (9), Vaginal swelling (7), Eyelid oedema (5). Outcome, 9 coded reports: Died leads at 100.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.