Drug profile

The FDA adverse-event record for Imidacloprid Pyriproxyfen

Name: Imidacloprid Pyriproxyfen - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

13 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid Pyriproxyfen. See the species affected, top reactions, and outcomes below.

13
adverse-event reports: 7.7%
death-coded share: Cat
most-reported species: 12
Lack of efficacy (ectoparasite) - flea - top reaction

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

7.7%

Death Rate

Active Ingredients

Imidacloprid Pyriproxyfen

Administration Routes

Topical

Species Affected

Cat 11

Dog 2

Most Affected Breeds

Cat (unknown) 4

Domestic Shorthair 3

Domestic Longhair 1

Corso Dog 1

Somali cat 1

Domestic Mediumhair 1

Mixed (Cat) 1

Shih Tzu 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 12

Skin disorders NOS 4

Twitching 3

Partial lack of efficacy 1

Death 1

Lack of efficacy - NOS 1

Outcome Breakdown

Outcome Unknown

12 (92.3%)

Died

1 (7.7%)

Imidacloprid Pyriproxyfen Adverse Event Insights

13 reports name Imidacloprid Pyriproxyfen; 1 recorded a death outcome (7.7% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid Pyriproxyfen. Administration route: Topical.

By species: Cat (11 reports), Dog (2 reports). By breed: Cat (unknown) (4), Domestic Shorthair (3), Domestic Longhair (1).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (12), Skin disorders NOS (4), Twitching (3), Partial lack of efficacy (1). Outcome, 13 coded reports: Outcome Unknown leads at 92.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.