Drug profile

The FDA adverse-event record for Imidacloprid Pyriproxyfen

13 FDA reports name Imidacloprid Pyriproxyfen, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2254 of 2,679
by report volume (all drugs)
13
adverse-event reports
7.7%
death-coded share
Cat
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imidacloprid Pyriproxyfen ranks #2210 of 2679 by total reports (13). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2210
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imidacloprid Pyriproxyfen has 13 reports now versus 13 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imidacloprid Pyriproxyfen changes

Signature read: 13 reports place Imidacloprid Pyriproxyfen in the lower third of FDA AER volume (#2254 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
1
Deaths Reported
7.7%
Death-coded share of reports

Active Ingredients

Imidacloprid Pyriproxyfen

Administration Routes

Topical

Species Affected

Cat 11
Dog 2

Most Affected Breeds

Cat (unknown) 4
Domestic Shorthair 3
Domestic Longhair 1
Corso Dog 1
Somali cat 1
Domestic Mediumhair 1
Mixed (Cat) 1
Shih Tzu 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 12
Skin disorders NOS 4
Twitching 3
Partial lack of efficacy 1
Death 1
Lack of efficacy - NOS 1

Outcome Breakdown

Outcome Unknown
12 (92.3%)
Died
1 (7.7%)

Imidacloprid Pyriproxyfen: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imidacloprid Pyriproxyfen (#2254 of 2,679 by report volume); death-coded 7.7%. PlainBreed drug row · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →