Drug profile

The FDA adverse-event record for Imidacloprid And Pyriproxyfen

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid And Pyriproxyfen. See the species affected, top reactions, and outcomes below.

15
adverse-event reports
6.7%
death-coded share
Dog
most-reported species
2
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
1
Deaths Reported
6.7%
Death Rate

Active Ingredients

Imidacloprid And Pyriproxyfen

Administration Routes

UnknownTopical

Species Affected

Dog 10
Cat 5

Most Affected Breeds

Terrier - Jack Russell 2
Domestic Shorthair 2
Cat (unknown) 2
Schnauzer (unspecified) 1
Domestic Longhair 1
Rottweiler 1
Dachshund - Miniature 1
Shih Tzu 1
Retriever - Labrador 1
Collie - Border 1

Most Reported Reactions

Vomiting 2
Anorexia 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Lack of efficacy (endoparasite) - heartworm 2
Tremor 2
Lethargy (see also Central nervous system depression in Neurological) 2
Rash 1
Death 1
Weight loss 1
INEFFECTIVE, ANTIEMETIC 1
Malaise 1
Dehydration 1

Outcome Breakdown

Ongoing
6 (40.0%)
Outcome Unknown
5 (33.3%)
Recovered/Normal
3 (20.0%)
Died
1 (6.7%)

Imidacloprid And Pyriproxyfen Adverse Event Insights

15 reports name Imidacloprid And Pyriproxyfen; 1 recorded a death outcome (6.7% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid And Pyriproxyfen. Administration routes: Unknown, Topical.

By species: Dog (10 reports), Cat (5 reports). By breed: Terrier - Jack Russell (2), Domestic Shorthair (2), Cat (unknown) (2).

Leading clinical signs: Vomiting (2), Anorexia (2), Lethargy (see also Central nervous system depression in 'Neurological') (2), Lack of efficacy (endoparasite) - heartworm (2). Outcome, 15 coded reports: Ongoing leads at 40.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.