Drug profile

The FDA adverse-event record for Ibuprofen

45 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ibuprofen. Species, reactions, and outcomes follow.

#1186 of 2,679
by report volume (all drugs)
45
adverse-event reports
8.9%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ibuprofen ranks #1182 of 2679 by total reports (45). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1182
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ibuprofen has 45 reports now versus 44 in that prior snapshot: 1 more (2.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ibuprofen changes

Signature read: report volume at 45 is the most distinctive stamp on Ibuprofen's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
45
Total Reports
4
Deaths Reported
8.9%
Death-coded share of reports

Active Ingredients

Ibuprofen

Administration Routes

OralUnknown

Species Affected

Dog 29
Human 16

Most Affected Breeds

Unknown 16
Retriever - Labrador 4
Dog (unknown) 3
Retriever - Golden 2
Terrier - Jack Russell 2
Shepherd Dog - Australian 2
Shih Tzu 2
Chihuahua 2
Dog (other) 1
Poodle - Standard 1

Most Reported Reactions

Vomiting 10
Accidental exposure 7
Fever 5
Diarrhoea 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Not eating 4
Anaemia NOS 3
Urine abnormalities NOS 3
Anorexia 3
Thrombocytopenia 3
Injection site pain 3
Elevated alanine aminotransferase (ALT) 3

Outcome Breakdown

Recovered/Normal
15 (33.3%)
Ongoing
14 (31.1%)
Outcome Unknown
12 (26.7%)
Died
3 (6.7%)
Euthanized
1 (2.2%)

Ibuprofen Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ibuprofen (#1186 of 2,679 by report volume); death-coded 8.9%. PlainBreed drug row · report volume stamp 45 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →