Drug profile

The FDA adverse-event record for High-Calorie Dietary Supplement

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference High-Calorie Dietary Supplement. See the species affected, top reactions, and outcomes below.

31
adverse-event reports
58.1%
death-coded share
Dog
most-reported species
16
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
18
Deaths Reported
58.1%
Death Rate

Active Ingredients

High-Calorie Dietary Supplement

Administration Routes

OralUnknown

Species Affected

Dog 16
Cat 15

Most Affected Breeds

Domestic Shorthair 10
Maltese 4
Chihuahua 4
Terrier - Yorkshire 3
Domestic Longhair 2
Shih Tzu 1
Cat (unknown) 1
Schnauzer - Miniature 1
Shepherd (unspecified) 1
Siamese 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 16
Anorexia 13
Death 11
Other abnormal test result NOS 9
Anaemia NOS 8
Seizure NOS 8
Hypoglycaemia 7
Elevated blood urea nitrogen (BUN) 6
Death by euthanasia 6
Leucocytosis NOS 5
Hyperphosphataemia 5
Hypothermia 5

Outcome Breakdown

Died
12 (38.7%)
Ongoing
10 (32.3%)
Euthanized
6 (19.4%)
Outcome Unknown
2 (6.5%)
Recovered/Normal
1 (3.2%)

High-Calorie Dietary Supplement Adverse Event Insights

31 reports name High-Calorie Dietary Supplement; 18 recorded a death outcome (58.1% of reported events, not a population-level mortality rate). Active ingredient: High-Calorie Dietary Supplement. Administration routes: Oral, Unknown.

By species: Dog (16 reports), Cat (15 reports). By breed: Domestic Shorthair (10), Maltese (4), Chihuahua (4).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (16), Anorexia (13), Death (11), Other abnormal test result NOS (9). Outcome, 31 coded reports: Died leads at 38.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.