Drug profile

Here's what the FDA CVM extract says about Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane

The CVM extract lists 10 reports for Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane, a lower-volume entry. Species, reactions, and outcomes are below.

#2590 of 2,679
by report volume (all drugs)
10
adverse-event reports
30.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane ranks #2536 of 2679 by total reports (10). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2536
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Signature read: 10 reports place Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane in the lower third of FDA AER volume (#2590 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
10
Total Reports
3
Deaths Reported
30.0%
Death-coded share of reports

Active Ingredients

Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane

Administration Routes

UnknownOral

Species Affected

Dog 10

Most Affected Breeds

Retriever - Labrador 2
Shepherd Dog - German 2
Bulldog - French 1
Terrier - Bull - American Pit 1
Beagle 1
Shepherd (unspecified) 1
Collie - Border 1
Shepherd Dog - Belgian Malinois 1

Most Reported Reactions

Abnormal radiograph finding 3
Unsteady gait 2
Grand mal seizure 2
Elevated globulins 2
Vomiting 2
Neutrophilia 2
Elevated serum alkaline phosphatase (ALP) 2
Death 2
Elevated blood urea nitrogen (BUN) 2
Other abnormal test result NOS 1
Weakness 1
Inappetence 1

Outcome Breakdown

Ongoing
5 (50.0%)
Recovered/Normal
2 (20.0%)
Died
2 (20.0%)
Euthanized
1 (10.0%)

Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Next steps with this data

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glucosamine Hydrochloride, Sodium Chondroitin Sulfate, And Methylsulfonylmethane (#2590 of 2,679 by report volume); death-coded 30.0%. PlainBreed drug row · report volume stamp 10 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →