Drug profile

The FDA adverse-event record for Glucosamine Hydrochloride

18 FDA reports name Glucosamine Hydrochloride, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1908 of 2,679
by report volume (all drugs)
18
adverse-event reports
5.6%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine Hydrochloride ranks #1884 of 2679 by total reports (18). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1884
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glucosamine Hydrochloride has 18 reports now versus 17 in that prior snapshot: 1 more (5.9%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glucosamine Hydrochloride changes

Signature read: death-coded report count at 1 is the most distinctive stamp on Glucosamine Hydrochloride's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
18
Total Reports
1
Deaths Reported
5.6%
Death-coded share of reports

Active Ingredients

Glucosamine Hydrochloride

Administration Routes

UnknownOralTopical

Species Affected

Dog 17
Cat 1

Most Affected Breeds

Boxer (German Boxer) 2
Retriever - Labrador 2
Shar Pei 2
Pointing Dog - Hungarian Short-haired (Vizsla) 1
Ridgeback - Rhodesian 1
Siberian Husky 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Shepherd Dog - German 1
Shepherd Dog - Belgian Malinois 1
Domestic Longhair 1

Most Reported Reactions

Lack of efficacy - NOS 5
Vomiting 3
Arthritis 3
Decreased appetite 2
Elevated alanine aminotransferase (ALT) 2
Low platelet count 2
Lameness 2
Abnormal cytology 2
Local swelling (not application site) 2
Difficulty going up/down stairs 2
Lying down 2
Joint ligament disorder NOS 2

Outcome Breakdown

Recovered/Normal
7 (38.9%)
Ongoing
6 (33.3%)
Outcome Unknown
4 (22.2%)
Died
1 (5.6%)

Glucosamine Hydrochloride: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glucosamine Hydrochloride (#1908 of 2,679 by report volume); death-coded 5.6%. PlainBreed drug row · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →