Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract
23 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 23 |
| Reports involving death | 5 |
| Case-fatality rate (reported events) | 2170.0% |
| Distinct species in reports | 1 |
| Distinct breeds in reports | 13 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 1 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 23 adverse event reports referencing Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract, including 5 reports in which the animal died — a 2170.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract. Reported administration routes include Oral, Unknown. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract reports are Dog (23 reports), with Dog accounting for the largest share. Within those species, Sheepdog - Shetland (5), Retriever - Labrador (5), Retriever - Golden (2) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract are Diarrhoea (7), Behavioural disorder NOS (6), Death (5), Abnormal stool colouration (5). Of the 23 reports with a coded outcome, Outcome Unknown is the leading category at 30.4%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.