Drug profile
The FDA adverse-event record for Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract
Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract appears in 23 FDA Center for Veterinary Medicine adverse-event reports. Read on for species, reactions, and outcomes.
- #1655 of 2,679
- by report volume (all drugs)
- 23
- adverse-event reports
- 21.7%
- death-coded share
- Dog
- most-reported species
Corpus placement
According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract ranks #1638 of 2679 by total reports (23). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).
- 149,624
- Milbemycin Oxime + Spinosad reports (#1)
- 97.8%
- Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
- #1638
- This drug, reports of 2679
Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract has 23 reports now versus 23 in that prior snapshot: 0 the same number of (0.0%).
- Report change
- +0
- Death-coded reports
- +0
- Death-coded share
- +0.0 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract changesSignature read: Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract's 21.7% death-coded share is among the highest in the openFDA drug corpus.
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Glucosamine Hcl (Shellfish), Methylsulfonylmethane (Msm), Creatine Monohydrate, Boswellia Serrata Extract: high death-coded share in the FDA AER row
Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.
Where to go from here
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full drug directory to compare report counts across products. All drugs
Correlation in adverse-event counts is not causation; consult a veterinarian before making a decision from this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →