Drug profile

The FDA adverse-event record for Folic Acid

28 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Folic Acid. Species, reactions, and outcomes follow.

#1501 of 2,679
by report volume (all drugs)
28
adverse-event reports
10.7%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Folic Acid ranks #1493 of 2679 by total reports (28). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1493
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Folic Acid has 28 reports now versus 27 in that prior snapshot: 1 more (3.7%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Folic Acid changes

Signature read: death-coded report count at 3 is the most distinctive stamp on Folic Acid's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
28
Total Reports
3
Deaths Reported
10.7%
Death-coded share of reports

Active Ingredients

Folic Acid

Administration Routes

UnknownOral

Species Affected

Dog 21
Cat 4
Human 3

Most Affected Breeds

Retriever - Labrador 3
Unknown 3
Domestic Shorthair 2
Retriever - Golden 2
Pit Bull 2
Coton de Tuléar 2
Newfoundland 1
Griffon - Brussels 1
Terrier - West Highland White 1
Cat (other) 1

Most Reported Reactions

Vomiting 7
Diarrhoea 5
Weight loss 4
Other abnormal test result NOS 4
Death 3
Behavioural disorder NOS 3
Anorexia 3
Anaemia NOS 3
Ataxia 3
Splenomegaly 2
Abnormal ultrasound finding 2
Immune mediated haemolytic anaemia 2

Outcome Breakdown

Ongoing
12 (42.9%)
Recovered/Normal
8 (28.6%)
Outcome Unknown
4 (14.3%)
Died
3 (10.7%)
Recovered with Sequela
1 (3.6%)

Folic Acid Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Folic Acid (#1501 of 2,679 by report volume); death-coded 10.7%. PlainBreed drug row · death-coded report count stamp 3 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →