Drug profile

The FDA adverse-event record for Flea Treatment (Unknown)

42 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Flea Treatment (Unknown). Species, reactions, and outcomes follow.

#1228 of 2,679
by report volume (all drugs)
42
adverse-event reports
2.4%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Flea Treatment (Unknown) ranks #1222 of 2679 by total reports (42). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1222
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Flea Treatment (Unknown) has 42 reports now versus 41 in that prior snapshot: 1 more (2.4%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Flea Treatment (Unknown) changes

Signature read: Flea Treatment (Unknown)'s 2.4% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
42
Total Reports
1
Deaths Reported
2.4%
Death-coded share of reports

Active Ingredients

Flea Treatment (Unknown)

Administration Routes

UnknownTopical

Species Affected

Dog 26
Cat 16

Most Affected Breeds

Domestic Shorthair 8
Dog (unknown) 5
Cat (unknown) 5
Shih Tzu 4
Terrier (unspecified) 3
Retriever - Golden 2
Domestic Longhair 2
Retriever - Labrador 2
Cat (other) 1
Dachshund - Miniature 1

Most Reported Reactions

Lack of efficacy (endoparasite) - tapeworm 8
Lack of efficacy (ectoparasite) - flea 7
Vomiting 3
Overdose 3
Itching 3
Diarrhoea 3
Other abnormal test result NOS 2
Application site hair loss 2
Weight gain 2
Scratching 2
Emesis (multiple) 2
Lack of efficacy (endoparasite) - heartworm 2

Outcome Breakdown

Outcome Unknown
25 (59.5%)
Ongoing
14 (33.3%)
Recovered/Normal
2 (4.8%)
Died
1 (2.4%)

Flea Treatment (Unknown): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Flea Treatment (Unknown) (#1228 of 2,679 by report volume); death-coded 2.4%. PlainBreed drug row · death-coded share stamp 2.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →