Fipronil + Cyphenothrin + (S)-Methoprene

25 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

400.0%

Death Rate

Active Ingredients

Fipronil + Cyphenothrin + (S)-Methoprene

Administration Routes

TopicalUnknownOral

Species Affected

Dog 16

Cat 9

Most Affected Breeds

Domestic Shorthair 7

Retriever - Labrador 4

Shih Tzu 4

Pit Bull 2

Domestic Longhair 1

Bichon Frise 1

Terrier - West Highland White 1

Beagle 1

Terrier (unspecified) 1

Schnauzer (unspecified) 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 7

Diarrhoea 7

Panting 3

Emesis 3

Vomiting 3

Behavioural disorder NOS 2

Weight loss 2

Ear flap oedema 2

External ear disorder NOS 2

Localised pain NOS (see other 'SOCs' for specific pain) 2

Localised oedema (not application site) 2

Localised rash 2

Outcome Breakdown

Recovered with Sequela

8 (32.0%)

Recovered/Normal

7 (28.0%)

Outcome Unknown

6 (24.0%)

Ongoing

3 (12.0%)

Euthanized

1 (4.0%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.