Drug profile

The FDA adverse-event record for Distemper/Lepto Vaccine

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Distemper/Lepto Vaccine. See the species affected, top reactions, and outcomes below.

15
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
2
Deaths Reported
13.3%
Death Rate

Active Ingredients

Distemper/Lepto Vaccine

Administration Routes

UnknownSubcutaneous

Species Affected

Dog 15

Most Affected Breeds

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 3
Dachshund - Standard Long-haired 1
Crossbred Canine/dog 1
Bulldog 1
Terrier (unspecified) 1
Collie - Border 1
Spaniel - Boykin 1
Poodle (unspecified) 1
Perro de Presa Canario 1
Terrier - Bull - American Pit 1

Most Reported Reactions

Vomiting 6
Diarrhoea 3
Facial swelling (see also Skin) 2
Lethargy (see also Central nervous system depression in Neurological) 2
Anaphylaxis 2
Dyspnoea 1
Dysphoria 1
Panting 1
Flatulence 1
Sudden death 1
Decreased appetite 1
Emesis (multiple) 1

Outcome Breakdown

Ongoing
7 (46.7%)
Recovered/Normal
5 (33.3%)
Died
1 (6.7%)
Outcome Unknown
1 (6.7%)
Euthanized
1 (6.7%)

Distemper/Lepto Vaccine Adverse Event Insights

15 reports name Distemper/Lepto Vaccine; 2 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). Active ingredient: Distemper/Lepto Vaccine. Administration routes: Unknown, Subcutaneous.

By species: Dog (15 reports). By breed: Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) (3), Dachshund - Standard Long-haired (1), Crossbred Canine/dog (1).

Leading clinical signs: Vomiting (6), Diarrhoea (3), Facial swelling (see also Skin) (2), Lethargy (see also Central nervous system depression in Neurological) (2). Outcome, 15 coded reports: Ongoing leads at 46.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.