Diphenhydramine Hydrochloride

14 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

1430.0%

Death Rate

Active Ingredients

Diphenhydramine Hydrochloride

Administration Routes

OralUnknownIntravenousParenteral

Species Affected

Dog 13

Cat 1

Most Affected Breeds

Retriever - Labrador 2

Crossbred Canine/dog 2

Rottweiler 2

Dalmatian 2

Schnauzer - Miniature 1

Pit Bull 1

Dog (unknown) 1

Domestic Shorthair 1

Terrier - American Staffordshire 1

Sheepdog - Long-haired Pyrenean 1

Most Reported Reactions

Pale mucous membrane 4

Allergic pruritus 3

Anaphylaxis 3

Lethargy (see also Central nervous system depression in Neurological) 3

Emesis 2

Other abnormal test result NOS 2

Death by euthanasia 2

Staggering 2

Low blood pressure 2

Lameness 2

Injection site swelling 2

Limping 2

Outcome Breakdown

Ongoing

5 (35.7%)

Recovered/Normal

4 (28.6%)

Outcome Unknown

3 (21.4%)

Euthanized

2 (14.3%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.