Drug profile

The FDA adverse-event record for Dihydrostreptomycin Sulfate; Procaine Penicillin

13 FDA reports name Dihydrostreptomycin Sulfate; Procaine Penicillin, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2237 of 2,679
by report volume (all drugs)
13
adverse-event reports
30.8%
death-coded share
Cattle
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dihydrostreptomycin Sulfate; Procaine Penicillin ranks #2210 of 2679 by total reports (13). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2210
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dihydrostreptomycin Sulfate; Procaine Penicillin has 13 reports now versus 13 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dihydrostreptomycin Sulfate; Procaine Penicillin changes

Signature read: Dihydrostreptomycin Sulfate; Procaine Penicillin's 30.8% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
4
Deaths Reported
30.8%
Death-coded share of reports

Active Ingredients

Dihydrostreptomycin Sulfate; Procaine Penicillin

Administration Routes

UnknownIntraocular

Species Affected

Cattle 8
Unknown 5

Most Affected Breeds

Cattle (other) 5
Unknown 5
Holstein-Friesian also known as Holstein 2
Jersey 1

Most Reported Reactions

Uncoded sign 2
Missing Cap 2
Caps, Abnormal 2
No sign 2
Death 2
Residues in meat/offal 1
Residues NOS 1
Tubes, Abnormal 1
Suspension, Abnormal 1
Dispenser, Abnormal 1
Containers, Leaking 1
Containers, Damaged 1

Outcome Breakdown

Outcome Unknown
5 (45.5%)
Euthanized
2 (18.2%)
Died
2 (18.2%)
Ongoing
1 (9.1%)
Recovered/Normal
1 (9.1%)

Dihydrostreptomycin Sulfate; Procaine Penicillin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dihydrostreptomycin Sulfate; Procaine Penicillin (#2237 of 2,679 by report volume); death-coded 30.8%. PlainBreed drug row · death-coded share stamp 30.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →