Drug profile

The FDA adverse-event record for Dihydrostreptomycin Sulfate; Procaine Penicillin

13 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dihydrostreptomycin Sulfate; Procaine Penicillin. See the species affected, top reactions, and outcomes below.

13
adverse-event reports
30.8%
death-coded share
Cattle
most-reported species
2
Uncoded sign - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
4
Deaths Reported
30.8%
Death Rate

Active Ingredients

Dihydrostreptomycin Sulfate; Procaine Penicillin

Administration Routes

UnknownIntraocular

Species Affected

Cattle 8
Unknown 5

Most Affected Breeds

Cattle (other) 5
Unknown 5
Holstein-Friesian also known as Holstein 2
Jersey 1

Most Reported Reactions

Uncoded sign 2
Missing Cap 2
Caps, Abnormal 2
No sign 2
Death 2
Residues in meat/offal 1
Residues NOS 1
Containers, Leaking 1
Tubes, Abnormal 1
Suspension, Abnormal 1
Dispenser, Abnormal 1
Underfilling, Package 1

Outcome Breakdown

Outcome Unknown
5 (45.5%)
Euthanized
2 (18.2%)
Died
2 (18.2%)
Ongoing
1 (9.1%)
Recovered/Normal
1 (9.1%)

Dihydrostreptomycin Sulfate; Procaine Penicillin Adverse Event Insights

13 reports name Dihydrostreptomycin Sulfate; Procaine Penicillin; 4 recorded a death outcome (30.8% of reported events, not a population-level mortality rate). Active ingredient: Dihydrostreptomycin Sulfate; Procaine Penicillin. Administration routes: Unknown, Intraocular.

By species: Cattle (8 reports), Unknown (5 reports). By breed: Cattle (other) (5), Unknown (5), Holstein-Friesian also known as Holstein (2).

Leading clinical signs: Uncoded sign (2), Missing Cap (2), Caps, Abnormal (2), No sign (2). Outcome, 11 coded reports: Outcome Unknown leads at 45.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.