Drug profile

The FDA adverse-event record for Clopidogrel Bisulfate

38 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clopidogrel Bisulfate. See the species affected, top reactions, and outcomes below.

38
adverse-event reports
42.1%
death-coded share
Dog
most-reported species
17
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
38
Total Reports
16
Deaths Reported
42.1%
Death Rate

Active Ingredients

Clopidogrel Bisulfate

Administration Routes

OralUnknown

Species Affected

Dog 30
Cat 8

Most Affected Breeds

Domestic Shorthair 6
Poodle (unspecified) 4
Shih Tzu 3
Pug 2
Retriever - Golden 2
Shepherd Dog - Australian 2
Mastiff 1
Beagle 1
Spaniel - Springer (unspecified) 1
Dachshund - Miniature 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 17
Immune mediated haemolytic anaemia 17
Anorexia 14
Death by euthanasia 12
Diarrhoea 11
Leucocytosis NOS 11
Pale mucous membrane 10
Anaemia NOS 9
Vomiting 9
Elevated total bilirubin 9
Elevated blood urea nitrogen (BUN) 9
Decreased appetite 6

Outcome Breakdown

Ongoing
15 (39.5%)
Euthanized
10 (26.3%)
Died
6 (15.8%)
Outcome Unknown
5 (13.2%)
Recovered/Normal
2 (5.3%)

Clopidogrel Bisulfate Adverse Event Insights

38 reports name Clopidogrel Bisulfate; 16 recorded a death outcome (42.1% of reported events, not a population-level mortality rate). Active ingredient: Clopidogrel Bisulfate. Administration routes: Oral, Unknown.

By species: Dog (30 reports), Cat (8 reports). By breed: Domestic Shorthair (6), Poodle (unspecified) (4), Shih Tzu (3).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (17), Immune mediated haemolytic anaemia (17), Anorexia (14), Death by euthanasia (12). Outcome, 38 coded reports: Ongoing leads at 39.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.