Drug profile

The FDA adverse-event record for Chlorhexidine Digluconate + Miconazole

Name: Chlorhexidine Digluconate + Miconazole - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

11 FDA reports name Chlorhexidine Digluconate + Miconazole, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2426 of 2,679
by report volume (all drugs): 11
adverse-event reports: 18.2%
death-coded share: Dog
most-reported species

Compiled by PlainBreed

Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Chlorhexidine Digluconate + Miconazole ranks #2412 of 2679 by total reports (11). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1): 97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1): #2412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Signature read: 11 reports place Chlorhexidine Digluconate + Miconazole in the lower third of FDA AER volume (#2426 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

18.2%

Death-coded share of reports

Active Ingredients

Chlorhexidine Digluconate + Miconazole

Administration Routes

TopicalUnknownAuricular (Otic)

Species Affected

Dog 10

Cat 1

Most Affected Breeds

Terrier (unspecified) 2

Terrier - West Highland White 2

Bulldog - French 2

Ridgeback - Rhodesian 1

Maltese 1

Domestic Shorthair 1

Spaniel - Cocker American 1

Shar Pei 1

Most Reported Reactions

Skin disorders NOS 5

Monocytosis 5

Leucocytosis NOS 5

Neutrophilia 5

Lethargy (see also Central nervous system depression in Neurological) 5

Behavioural disorder NOS 5

Malaise 5

Vomiting 4

Alopecia local 3

Pinnae disorder 3

Platelet disorder NOS 3

Crust 3

Outcome Breakdown

Outcome Unknown

4 (36.4%)

Ongoing

3 (27.3%)

Euthanized

2 (18.2%)

Recovered/Normal

2 (18.2%)

Chlorhexidine Digluconate + Miconazole: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Chlorhexidine Digluconate + Miconazole (#2426 of 2,679 by report volume); death-coded 18.2%. PlainBreed drug row · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →