Drug profile

The FDA adverse-event record for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain

85 FDA reports name Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#854 of 2,679
by report volume (all drugs)
85
adverse-event reports
16.5%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain ranks #851 of 2679 by total reports (85) and #321 of 1130 by death-coded share (16.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#851
This drug, reports of 2679
#321
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain has 85 reports now versus 85 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain changes

Signature read: death-coded report count at 14 is the most distinctive stamp on Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
85
Total Reports
14
Deaths Reported
16.5%
Death-coded share of reports

Active Ingredients

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain

Administration Routes

Subcutaneous

Species Affected

Dog 85

Most Affected Breeds

Retriever - Labrador 12
Chihuahua 9
Terrier - Yorkshire 8
Rottweiler 4
Beagle 3
Pinscher - Miniature 3
Weimaraner 3
Retriever - Golden 3
Boxer (German Boxer) 3
Terrier - Jack Russell 3

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 23
Vomiting 23
Diarrhoea 17
Other abnormal test result NOS 15
Elevated serum alkaline phosphatase (SAP) 10
Fever 9
Leucocytosis NOS 9
Anorexia 9
Death by euthanasia 8
Hypoalbuminaemia 8
Lack of efficacy - NOS 8
Decreased appetite 8

Outcome Breakdown

Ongoing
45 (50.6%)
Recovered/Normal
26 (29.2%)
Euthanized
8 (9.0%)
Died
6 (6.7%)
Outcome Unknown
4 (4.5%)

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (16.5% here), distinct from the volume row.

Laser Treatment 16.5% Unspecified Joint Supplement 16.5% Insulin 16.5% Gabapentin 16.5%

What to do with this drug

  • Compare Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Coronavirus, Strain (#854 of 2,679 by report volume); death-coded 16.5%. PlainBreed drug row · death-coded report count stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →