Drug profile

The FDA adverse-event record for Calcium Supplement

11 FDA reports name Calcium Supplement, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2423 of 2,679
by report volume (all drugs)
11
adverse-event reports
27.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Calcium Supplement ranks #2412 of 2679 by total reports (11). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Calcium Supplement has 11 reports now versus 10 in that prior snapshot: 1 more (10.0%).

Report change
+1
Death-coded reports
+0
Death-coded share
−2.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Calcium Supplement changes

Signature read: 11 reports place Calcium Supplement in the lower third of FDA AER volume (#2423 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
3
Deaths Reported
27.3%
Death-coded share of reports

Active Ingredients

Calcium Supplement

Administration Routes

UnknownOral

Species Affected

Dog 5
Cat 4
Horse 1
Cattle 1

Most Affected Breeds

Domestic Shorthair 2
Pug 1
Holsteiner 1
Shepherd Dog - Dutch 1
Siamese 1
Siberian 1
Shiba Inu 1
Holstein-Friesian also known as Holstein 1
Retriever - Chesapeake Bay 1
Terrier - Bull - Staffordshire 1

Most Reported Reactions

Behavioural disorder NOS 3
Death 2
Vomiting 2
Hypotension 2
Hypocalcaemia 2
Dehydration 2
Lethargy (see also Central nervous system depression in Neurological) 2
Respiratory signs 1
Polyuria 1
Polydipsia 1
Thrombocytopenia 1
Elevated gamma-glutamyl transferase (GGT) 1

Outcome Breakdown

Outcome Unknown
4 (36.4%)
Ongoing
3 (27.3%)
Died
2 (18.2%)
Recovered/Normal
1 (9.1%)
Euthanized
1 (9.1%)

Calcium Supplement: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Calcium Supplement (#2423 of 2,679 by report volume); death-coded 27.3%. PlainBreed drug row · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →