Drug profile

The FDA adverse-event record for Calcium

43 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Calcium. Species, reactions, and outcomes follow.

#1213 of 2,679
by report volume (all drugs)
43
adverse-event reports
25.6%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Calcium ranks #1213 of 2679 by total reports (43). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1213
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Calcium has 43 reports now versus 42 in that prior snapshot: 1 more (2.4%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Calcium changes

Signature read: Calcium's 25.6% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
43
Total Reports
11
Deaths Reported
25.6%
Death-coded share of reports

Active Ingredients

Calcium

Administration Routes

UnknownOralIntravenousSubcutaneous

Species Affected

Dog 16
Human 10
Cat 8
Cattle 6
Other 1
Goat 1
Horse 1

Most Affected Breeds

Unknown 11
Domestic Shorthair 6
Holstein-Friesian also known as Holstein 3
Retriever - Labrador 3
Pit Bull 2
Jersey 2
Schnauzer (unspecified) 1
Boxer (German Boxer) 1
Domestic Longhair 1
Terrier - Scottish 1

Most Reported Reactions

Vomiting 6
Lethargy (see also Central nervous system depression in 'Neurological') 6
Other abnormal test result NOS 6
Death 6
Diarrhoea 5
Accidental exposure 5
Anaemia NOS 4
Dehydration 4
Death by euthanasia 4
Not eating 4
Emesis 3
Weight loss 3

Outcome Breakdown

Recovered/Normal
13 (29.5%)
Ongoing
12 (27.3%)
Died
7 (15.9%)
Outcome Unknown
7 (15.9%)
Euthanized
4 (9.1%)
Recovered with Sequela
1 (2.3%)

Calcium: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Calcium (#1213 of 2,679 by report volume); death-coded 25.6%. PlainBreed drug row · death-coded share stamp 25.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →