Drug profile

The FDA adverse-event record for Amoxicillin And Clavulanic Acid

26 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin And Clavulanic Acid. See the species affected, top reactions, and outcomes below.

26
adverse-event reports
19.2%
death-coded share
Dog
most-reported species
5
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
26
Total Reports
5
Deaths Reported
19.2%
Death Rate

Active Ingredients

Amoxicillin And Clavulanic Acid

Administration Routes

OralUnknown

Species Affected

Dog 19
Cat 7

Most Affected Breeds

Domestic Shorthair 5
Terrier - Yorkshire 2
Dachshund - Standard Long-haired 2
Retriever - Labrador 2
Bulldog - French 2
Terrier - Bull - American Pit 2
Domestic Mediumhair 1
Lhasa Apso 1
Retriever - Golden 1
Maltese 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 5
Fever 4
Seizure NOS 4
Other abnormal test result NOS 3
Diarrhoea 3
Anaemia NOS 3
Death 3
Anorexia 3
Elevated blood urea nitrogen (BUN) 3
Hind limb paresis 3
Elevated alanine aminotransferase (ALT) 3
Elevated serum alkaline phosphatase (SAP) 3

Outcome Breakdown

Recovered/Normal
8 (30.8%)
Outcome Unknown
8 (30.8%)
Ongoing
5 (19.2%)
Died
3 (11.5%)
Euthanized
2 (7.7%)

Amoxicillin And Clavulanic Acid Adverse Event Insights

26 reports name Amoxicillin And Clavulanic Acid; 5 recorded a death outcome (19.2% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin And Clavulanic Acid. Administration routes: Oral, Unknown.

By species: Dog (19 reports), Cat (7 reports). By breed: Domestic Shorthair (5), Terrier - Yorkshire (2), Dachshund - Standard Long-haired (2).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (5), Fever (4), Seizure NOS (4), Other abnormal test result NOS (3). Outcome, 26 coded reports: Recovered/Normal leads at 30.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.