Drug profile

The FDA adverse-event record for Allopurinol

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Allopurinol. See the species affected, top reactions, and outcomes below.

15
adverse-event reports
20.0%
death-coded share
Dog
most-reported species
2
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
3
Deaths Reported
20.0%
Death Rate

Active Ingredients

Allopurinol

Administration Routes

UnknownOral

Species Affected

Dog 10
Human 4
Other Birds 1

Most Affected Breeds

Dalmatian 7
Unknown 5
Bichon Frise 1
Pug 1
Bulldog - English 1

Most Reported Reactions

Emesis 2
Reluctant to move 2
Death 2
Lack of efficacy - NOS 2
Leucocytosis NOS 2
Lack of efficacy (ectoparasite) - flea 1
Eye irritation 1
Accidental exposure 1
Sudden death 1
Hair loss NOS 1
Abnormal posture NOS 1
Petechiae NOS 1

Outcome Breakdown

Outcome Unknown
6 (40.0%)
Ongoing
4 (26.7%)
Died
3 (20.0%)
Recovered/Normal
2 (13.3%)

Allopurinol Adverse Event Insights

15 reports name Allopurinol; 3 recorded a death outcome (20.0% of reported events, not a population-level mortality rate). Active ingredient: Allopurinol. Administration routes: Unknown, Oral.

By species: Dog (10 reports), Human (4 reports), Other Birds (1 reports). By breed: Dalmatian (7), Unknown (5), Bichon Frise (1).

Leading clinical signs: Emesis (2), Reluctant to move (2), Death (2), Lack of efficacy - NOS (2). Outcome, 15 coded reports: Outcome Unknown leads at 40.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.