Drug profile

The FDA adverse-event record for 114 Mg Praziquantel/114 Mg Pyrantel

44 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference 114 Mg Praziquantel/114 Mg Pyrantel. See the species affected, top reactions, and outcomes below.

44
adverse-event reports
2.3%
death-coded share
Dog
most-reported species
18
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
44
Total Reports
1
Deaths Reported
2.3%
Death Rate

Active Ingredients

114 Mg Praziquantel/114 Mg Pyrantel

Administration Routes

OralUnknown

Species Affected

Dog 39
Unknown 3
Cat 2

Most Affected Breeds

Retriever - Labrador 10
Dog (unknown) 4
Retriever - Golden 3
Unknown 3
Shepherd Dog - German 3
Crossbred Canine/dog 2
Domestic Shorthair 2
Alaskan Malamute 1
Spaniel (unspecified) 1
Poodle - Toy 1

Most Reported Reactions

Vomiting 18
Lack of efficacy (endoparasite) - tapeworm 8
INEFFECTIVE, HOOKS 7
Drug dose administration interval too long 7
Lack of efficacy - NOS 5
INEFFECTIVE, ASCARIDS NOS 3
Lethargy (see also Central nervous system depression in 'Neurological') 3
Diarrhoea 3
Overdose 3
Vocalisation 2
Limb weakness 2
Ataxia 2

Outcome Breakdown

Outcome Unknown
19 (46.3%)
Recovered/Normal
18 (43.9%)
Ongoing
3 (7.3%)
Died
1 (2.4%)

114 Mg Praziquantel/114 Mg Pyrantel Adverse Event Insights

44 reports name 114 Mg Praziquantel/114 Mg Pyrantel; 1 recorded a death outcome (2.3% of reported events, not a population-level mortality rate). Active ingredient: 114 Mg Praziquantel/114 Mg Pyrantel. Administration routes: Oral, Unknown.

By species: Dog (39 reports), Unknown (3 reports), Cat (2 reports). By breed: Retriever - Labrador (10), Dog (unknown) (4), Retriever - Golden (3).

Leading clinical signs: Vomiting (18), Lack of efficacy (endoparasite) - tapeworm (8), INEFFECTIVE, HOOKS (7), Drug dose administration interval too long (7). Outcome, 41 coded reports: Outcome Unknown leads at 46.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.