Total Reports
12
FDA CVM filings
Cat /
2026 FDA CVM data 12 reports on file official source
Exotic — FDA Adverse Event Profile
Adverse-event records and label data for Exotic (Cat), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.
Exotic (Cat) has 12 FDA adverse event reports on record, with 1 deaths reported (830.0% death rate) — ranking #424 by report volume. The most frequently reported reaction is Behavioural disorder NOS (3 cases). The top associated drug is Lotilaner. Average age at report: 7.7 years.
Deaths Reported
1
of 12 reports
Death Rate
830.0%
death-coded share
Avg Age at Report
7.7 yr
4.5 kg avg weight
Death-Coded Outcome Share
Exotic death-coded reports 100.0%
Database median
830.0% of 12 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 4.5 kg (9.9 lbs)
Top Reported Reactions
Behavioural disorder NOS 3
Ataxia 3
Lethargy (see also Central nervous system depression in Neurological) 2
Hyperglycaemia 2
Dilated pupils 2
Weakness 2
Squinting 2
Licking 2
Chewing - pruritus (see also Oral cavity disorders) 2
Hypersensitivity NOS 2
Hyperactivity 2
Death by euthanasia 1
Paralysis 1
Application site alopecia 1
Sedation 1
Most Referenced Drugs
Lotilaner 3
Buprenorphine 2
Eprinomectin + Esafoxolaner + Praziquantel 2
Immunotherapy 2
Cetirizine 2
Dexamethasone 2
Cefovecin 1
Fluralaner Spot-On Solution 1
Spinosad 1
Bexagliflozin 1
Insulin Glargine 1
Frunevetmab 1
Outcome Breakdown
Outcome Unknown
5 (41.7%)
Ongoing
4 (33.3%)
Recovered/Normal
2 (16.7%)
Euthanized
1 (8.3%)
Gender Distribution
Female 7 (58.3%)
Male 5 (41.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2019 | 1 | |
| 2020 | 1 | |
| 2022 | 2 | |
| 2023 | 2 | |
| 2024 | 3 | |
| 2025 | 3 | |
Exotic Pet Health Insights
Across the FDA Center for Veterinary Medicine adverse event database, Exotic accounts for 12 submitted reports and currently ranks #424 by report volume within the cat population. Of those reports, 1 involved a death outcome — a 830.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 7.7 years, with an average recorded body weight of 4.5 kg (9.9 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.
The most frequently reported clinical signs for Exotic are Behavioural disorder NOS (3 reports), Ataxia (3 reports), Lethargy (see also Central nervous system depression in Neurological) (2 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Lotilaner appears in 3 reports and is the single most-referenced drug, followed by Buprenorphine (2) and Eprinomectin + Esafoxolaner + Praziquantel (2). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same cat species.
Outcome coding on the 12 reports with a recorded status is dominated by Outcome Unknown (41.7% of coded outcomes). Annual submission volume ranges from 2,019 to 2,025 reports across the 6 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual cat.
Understanding Exotic Adverse Event Data
Exotic has 12 adverse event reports on file. Lower report volumes may reflect a less common breed, lower reporting rates, or genuinely fewer adverse events.
The 830.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.
The most frequently referenced drug in adverse reports is Lotilaner, appearing in 3 reports. This may indicate widespread use of the medication rather than a specific safety concern for Exotic.
Other Cat Breeds
Domestic Shorthair
61,410 reports · 720.0% death rate
Cat (unknown)
12,555 reports · 930.0% death rate
Domestic Longhair
9,078 reports · 690.0% death rate
Domestic (unspecified)
7,559 reports · 1340.0% death rate
Domestic Mediumhair
6,057 reports · 760.0% death rate
Cat (other)
4,619 reports · 970.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Exotic? ▼
There are 12 adverse event reports involving Exotic in the FDA database, with 1 reports involving death (830.0% death rate). Exotic ranks #424 by report volume.
What are the most common adverse reactions reported for Exotic? ▼
The most commonly reported adverse reactions for Exotic are Behavioural disorder NOS (3 reports), Ataxia (3 reports), Lethargy (see also Central nervous system depression in Neurological) (2 reports), Hyperglycaemia (2 reports), Dilated pupils (2 reports).
What drugs are most frequently associated with Exotic adverse events? ▼
The drugs most frequently referenced in Exotic adverse event reports are Lotilaner (3 reports), Buprenorphine (2 reports), Eprinomectin + Esafoxolaner + Praziquantel (2 reports), Immunotherapy (2 reports), Cetirizine (2 reports).
What is the average age of Exotic in adverse event reports? ▼
The average age of Exotic at the time of adverse event reports is 7.7 years, with an average weight of 4.5 kg (9.9 lbs).
Does a high number of adverse event reports mean Exotic is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Exotic safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Guides & Resources
Understanding Adverse Events
What FDA reports are and how they are collected
Breed-Specific Risks
Why some breeds appear in more adverse event reports
Pet Medication Safety
Evaluating medication risks using FDA data
Most Reported Medications
Drugs that appear most in adverse event reports
How FDA CVM Tracks Events
The reporting process and database limitations
Related Data Sources
Data Sources & Methodology
Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.
Exotic ranks #424 by total report volume. Death rate (830.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.
Read our methodology — how this data is sourced, computed, and verified.
Related
Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial