Reaction profile

The FDA adverse-event record for muscle atrophy (see also 'muscle wasting')

193 FDA adverse-event reports reference muscle atrophy (see also 'muscle wasting') (VeDDRA 2470). See the species, breeds, and drugs most associated with it below.

193
reports citing this reaction
23.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
193
Total Reports
46
Deaths
23.8%
Death Rate

Species Most Affected

Dog 157
Cat 24
Horse 12

Breeds Most Affected

Retriever - Labrador 30
Domestic Shorthair 14
Retriever - Golden 12
Crossbred Canine/dog 9
Shepherd Dog - German 7
Terrier - Bull - American Pit 7
Shepherd Dog - Australian 5
Beagle 5
Dog (unknown) 5
Spaniel - Springer English 4

Associated Drugs

Trilostane 25
Fluralaner Chew Tablets 22
Prednisone 16
Carprofen 14
Gabapentin 14
Moxidectin 11
Afoxolaner 10
Milbemycin Oxime + Spinosad 10
Maropitant Citrate 9
Oclacitinib Maleate 8
Grapiprant 8
Fluralaner 13.64% 12-Week Chew 8
Dexamethasone 7
Melarsomine Dihydrochloride 7
Milbemycin Oxime + Praziquantel 7
Enrofloxacin 6
Ivermectin + Pyrantel As Pamoate Salt 6
Polysulfated Glycosaminoglycan 5
Ceftiofur Crystalline Free Acid 5
Melarsomine Dihydrochloride Injection 5

Muscle atrophy (see also 'Muscle wasting') Reaction Insights

193 reports name Muscle atrophy (see also 'Muscle wasting'); 46 recorded a death outcome (23.8% of reported events, not a population-level mortality rate). VeDDRA code: 2470.

By species: Dog (157 reports), Cat (24 reports), Horse (12 reports). By breed: Retriever - Labrador (30), Domestic Shorthair (14), Retriever - Golden (12).

Most co-reported drugs: Trilostane (25 reports), Fluralaner Chew Tablets (22 reports), Prednisone (16 reports), Carprofen (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.