Reaction profile

The FDA adverse-event record for monocytopenia

134 FDA adverse-event reports reference monocytopenia (VeDDRA 99287). See the species, breeds, and drugs most associated with it below.

134
reports citing this reaction
29.9%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
134
Total Reports
40
Deaths
29.9%
Death Rate

Species Most Affected

Dog 124
Cat 9
Horse 1

Breeds Most Affected

Retriever - Golden 8
Crossbred Canine/dog 7
Retriever - Labrador 7
Shih Tzu 6
Shepherd Dog - German 5
Domestic (unspecified) 5
Dachshund (unspecified) 5
Bulldog - French 5
Pit Bull 4
Boxer (German Boxer) 4

Associated Drugs

Oclacitinib Maleate 22
Carprofen 13
Milbemycin Oxime + Spinosad 12
Ivermectin + Pyrantel As Pamoate Salt 10
Spinosad 8
Polysulfated Glycosaminoglycan 7
Firocoxib 6
Moxidectin 6
Maropitant Citrate 6
Grapiprant 6
Cefovecin Sodium 5
Afoxolaner 5
Selamectin 4
Cefpodoxime Proxetil 4
Imidacloprid + Moxidectin 3
Deracoxib 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 3
Prednisone 3
Cyclosporine A 3
Famotidine 3

MONOCYTOPENIA Reaction Insights

134 reports name MONOCYTOPENIA; 40 recorded a death outcome (29.9% of reported events, not a population-level mortality rate). VeDDRA code: 99287.

By species: Dog (124 reports), Cat (9 reports), Horse (1 reports). By breed: Retriever - Golden (8), Crossbred Canine/dog (7), Retriever - Labrador (7).

Most co-reported drugs: Oclacitinib Maleate (22 reports), Carprofen (13 reports), Milbemycin Oxime + Spinosad (12 reports), Ivermectin + Pyrantel As Pamoate Salt (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.