Reaction profile

The FDA adverse-event record for limb amputation

18 FDA adverse-event reports reference limb amputation (VeDDRA 93099). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
18
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 17
Cat 1

Breeds Most Affected

Dog (unknown) 3
Terrier - Yorkshire 2
Chihuahua 2
Boxer (German Boxer) 2
Pit Bull 2
Shepherd Dog - Dutch 1
Crossbred Canine/dog 1
Retriever - Labrador 1
Dachshund (unspecified) 1
Pinscher - Miniature 1

Associated Drugs

Tigilanol Tiglate 12
Device: Surgical Instruments 3
Device: Bandaging 1
Alphaxolone 1
Buprenorphine Hydrochloride 1
Milbemycin Oxime + Spinosad 1
Dexmedetomidine 1
Butorphanol 1
Atipamezole 1
Robenacoxib 1

LIMB AMPUTATION Reaction Insights

18 reports name LIMB AMPUTATION; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 93099.

By species: Dog (17 reports), Cat (1 reports). By breed: Dog (unknown) (3), Terrier - Yorkshire (2), Chihuahua (2).

Most co-reported drugs: Tigilanol Tiglate (12 reports), Device: Surgical Instruments (3 reports), Device: Bandaging (1 reports), Alphaxolone (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.