Reaction profile

The FDA adverse-event record for lack of efficacy (ectoparasite nos)

39 FDA adverse-event reports reference lack of efficacy (ectoparasite nos) (VeDDRA 2492). See the species, breeds, and drugs most associated with it below.

39
reports citing this reaction
5.1%
death-coded share
Dog
most-affected species
Doramectin
most-associated drug
Verify with FDA CVM →
39
Total Reports
2
Deaths
5.1%
Death Rate

Species Most Affected

Dog 21
Cattle 14
Cat 3
Sheep 1

Breeds Most Affected

Mixed (Cattle) 9
Dog (unknown) 8
Crossbred Canine/dog 3
Aberdeen Angus 2
Schnauzer - Miniature 2
Retriever - Labrador 1
Charolais 1
Cat (other) 1
Boxer (German Boxer) 1
Cattle (unknown) 1

Associated Drugs

Doramectin 12
Fluralaner 13.64% 12-Week Chew 5
Selamectin 4
Fluralaner Chew Tablets 4
Milbemycin Oxime + Spinosad 4
Afoxolaner 68 Mg Chewable Tablets 3
Anti-Il31 Mab Mcs Lot #1283563 2
Ivermectin 0.5% Pour-On Topical Solution 2
Eprinomectin 2
Fluralaner Spot-On Solution 2
Afoxolaner 11.3 Mg Chewable Tablets 1
Oclacitinib Maleate 1
Afoxolaner 28.3 Mg Chewable Tablets 1
Spinosad 1
Sarolaner 1
Tulathromycin 1
Lotilaner 1

Lack of efficacy (ectoparasite NOS) Reaction Insights

39 reports name Lack of efficacy (ectoparasite NOS); 2 recorded a death outcome (5.1% of reported events, not a population-level mortality rate). VeDDRA code: 2492.

By species: Dog (21 reports), Cattle (14 reports), Cat (3 reports). By breed: Mixed (Cattle) (9), Dog (unknown) (8), Crossbred Canine/dog (3).

Most co-reported drugs: Doramectin (12 reports), Fluralaner 13.64% 12-Week Chew (5 reports), Selamectin (4 reports), Fluralaner Chew Tablets (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.