Reaction profile

The FDA adverse-event record for hives (see also skin)

1,445 FDA adverse-event reports reference hives (see also skin) (VeDDRA 1525). See the species, breeds, and drugs most associated with it below.

1,445
reports citing this reaction
0.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
1,445
Total Reports
13
Deaths
0.9%
Death Rate

Species Most Affected

Dog 1,332
Horse 66
Cat 20
Human 16
Cattle 9
Other 1
Ferret 1

Breeds Most Affected

Terrier - Bull - American Pit 161
Retriever - Labrador 107
Crossbred Canine/dog 95
Boxer (German Boxer) 91
Bulldog - French 78
Chihuahua 66
Terrier - Boston 53
Pit Bull 42
Dachshund (unspecified) 39
Terrier - Bull - Staffordshire 33

Associated Drugs

Moxidectin 500
Pyrantel Pamoate;Sarolaner 130
Rabies Virus, Kv 122
Anti-Il31 Mab Mcs Lot #1283563 94
Maropitant Citrate 91
Oclacitinib Maleate 85
Diphenhydramine 84
Afoxolaner 77
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 75
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 69
Fluralaner 13.64% 12-Week Chew 66
Rabies Vaccine 53
Bedinvetmab 50
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str 43
Carprofen 42
Milbemycin Oxime + Praziquantel 42
Lotilaner 33
Prednisone 31
Melarsomine Dihydrochloride 30
Gabapentin 28

Hives (see also Skin) Reaction Insights

1,445 reports name Hives (see also Skin); 13 recorded a death outcome (0.9% of reported events, not a population-level mortality rate). VeDDRA code: 1525.

By species: Dog (1,332 reports), Horse (66 reports), Cat (20 reports). By breed: Terrier - Bull - American Pit (161), Retriever - Labrador (107), Crossbred Canine/dog (95).

Most co-reported drugs: Moxidectin (500 reports), Pyrantel Pamoate;Sarolaner (130 reports), Rabies Virus, Kv (122 reports), Anti-Il31 Mab Mcs Lot #1283563 (94 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.