Reaction profile

The FDA adverse-event record for face and neck swelling (see also skin)

37 FDA adverse-event reports reference face and neck swelling (see also skin) (VeDDRA 1462). See the species, breeds, and drugs most associated with it below.

37
reports citing this reaction
13.5%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
37
Total Reports
5
Deaths
13.5%
Death Rate

Species Most Affected

Dog 30
Horse 5
Cattle 1
Cat 1

Breeds Most Affected

Retriever - Labrador 6
Quarter Horse 4
Dachshund (unspecified) 3
Crossbred Canine/dog 3
Boxer (German Boxer) 3
Chihuahua 2
Terrier - Bull - American Pit 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Bulldog - French 1
Mixed (Cattle) 1

Associated Drugs

Maropitant Citrate 6
Moxidectin 6
Oclacitinib Maleate 5
Bedinvetmab 4
Prednisone 3
Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 3
Trenbolone Acetate;Estradiol Benzoate 3
Fluralaner 13.64% 12-Week Chew 3
Cefovecin 3
Detomidine Hydrochloride 3
Tigilanol Tiglate 2
Diphenhydramine 2
Tylosin Tartrate 2
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 2
Rabies Vaccine, Killed Virus 2
Chlorhexidine Digluconate + Tris-Edta 2
Vaccine (Unknown) 2
Cefpodoxime 2
Carprofen 2
Grapiprant 2

Face and neck swelling (see also Skin) Reaction Insights

37 reports name Face and neck swelling (see also Skin); 5 recorded a death outcome (13.5% of reported events, not a population-level mortality rate). VeDDRA code: 1462.

By species: Dog (30 reports), Horse (5 reports), Cattle (1 reports). By breed: Retriever - Labrador (6), Quarter Horse (4), Dachshund (unspecified) (3).

Most co-reported drugs: Maropitant Citrate (6 reports), Moxidectin (6 reports), Oclacitinib Maleate (5 reports), Bedinvetmab (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.