Reaction profile

The FDA adverse-event record for eye paralysis (for miosis etc see 'neurological')

19 FDA adverse-event reports reference eye paralysis (for miosis etc see 'neurological') (VeDDRA 454). See the species, breeds, and drugs most associated with it below.

19
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
19
Total Reports
2
Deaths
10.5%
Death Rate

Species Most Affected

Dog 16
Cat 3

Breeds Most Affected

Domestic Shorthair 2
Lhasa Apso 2
Retriever - Labrador 1
Sheepdog - Shetland 1
Terrier - West Highland White 1
Terrier - Jack Russell 1
Mountain Dog - Bernese 1
Persian 1
Spitz - German Pomeranian 1
Terrier - Bull 1

Associated Drugs

Trilostane 5
Maropitant Citrate 3
Milbemycin Oxime + Spinosad 2
Afoxolaner 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Cephalexin 1
Spinosad 1
Dexamethasone 1
Afoxolaner 2.27% Chewable Tablet (28.3 Mg) 1
Ivermectin 68Mcg Pyrantel 57Mg 1
Genta/Momet/Clotrim Ear Oint 1
Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride 1
Cefovecin 1
Enrofloxacin + Silver Sulfadiazine 1
Fluocinolone Acetonide 1
Unknown Solution 1
Lanolin/Mineral Oil/White Petrolatum 1
Bacitracin/Polymyxin 1
Nitenpyram 1
Betamethasone + Florfenicol + Terbinafine 1

Eye paralysis (for Miosis etc see 'Neurological') Reaction Insights

19 reports name Eye paralysis (for Miosis etc see 'Neurological'); 2 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). VeDDRA code: 454.

By species: Dog (16 reports), Cat (3 reports). By breed: Domestic Shorthair (2), Lhasa Apso (2), Retriever - Labrador (1).

Most co-reported drugs: Trilostane (5 reports), Maropitant Citrate (3 reports), Milbemycin Oxime + Spinosad (2 reports), Afoxolaner (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.