Reaction profile

The FDA adverse-event record for eosinopenia

271 FDA adverse-event reports reference eosinopenia (VeDDRA 99244). See the species, breeds, and drugs most associated with it below.

271
reports citing this reaction
30.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
271
Total Reports
83
Deaths
30.6%
Death Rate

Species Most Affected

Dog 235
Cat 36

Breeds Most Affected

Retriever - Labrador 23
Domestic Shorthair 16
Retriever - Golden 15
Domestic (unspecified) 12
Chihuahua 12
Crossbred Canine/dog 9
Shih Tzu 8
Terrier - Yorkshire 8
Beagle 8
Dachshund (unspecified) 8

Associated Drugs

Milbemycin Oxime + Spinosad 41
Spinosad 23
Carprofen 21
Moxidectin 21
Maropitant Citrate 18
Fluralaner Chew Tablets 17
Meloxicam 15
Afoxolaner 13
Trilostane 12
Tramadol 12
Ivermectin + Pyrantel As Pamoate Salt 12
Grapiprant 11
Oclacitinib Maleate 9
Maropitant 8
Cefovecin Sodium 8
Deracoxib 8
Polysulfated Glycosaminoglycan 8
Prednisone 7
Famotidine 7
Enrofloxacin 7

EOSINOPENIA Reaction Insights

271 reports name EOSINOPENIA; 83 recorded a death outcome (30.6% of reported events, not a population-level mortality rate). VeDDRA code: 99244.

By species: Dog (235 reports), Cat (36 reports). By breed: Retriever - Labrador (23), Domestic Shorthair (16), Retriever - Golden (15).

Most co-reported drugs: Milbemycin Oxime + Spinosad (41 reports), Spinosad (23 reports), Carprofen (21 reports), Moxidectin (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.