Reaction profile

The FDA adverse-event record for collapse (see also cardio-vascular and systemic disorders)

323 FDA adverse-event reports reference collapse (see also cardio-vascular and systemic disorders) (VeDDRA 668). See the species, breeds, and drugs most associated with it below.

323
reports citing this reaction
37.2%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
323
Total Reports
120
Deaths
37.2%
Death Rate

Species Most Affected

Dog 277
Cat 30
Horse 13
Cattle 3

Breeds Most Affected

Crossbred Canine/dog 20
Retriever - Labrador 16
Terrier - Yorkshire 14
Domestic Shorthair 13
Retriever - Golden 12
Shepherd Dog - German 11
Boxer (German Boxer) 11
Terrier - Bull - American Pit 10
Shepherd Dog - Australian 10
Shih Tzu 10

Associated Drugs

Bedinvetmab 82
Moxidectin 55
Maropitant Citrate 30
Pyrantel Pamoate;Sarolaner 26
Gabapentin 21
Carprofen 19
Afoxolaner 16
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 14
Oclacitinib Maleate 12
Rabies Virus, Kv 12
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 12
Milbemycin Oxime + Praziquantel 11
Anti-Il31 Mab Mcs Lot #1283563 10
Fluralaner 13.64% 12-Week Chew 8
Pimobendan 8
Trazodone 8
Frunevetmab 7
Butorphanol Tartrate 7
Lotilaner 7
Melarsomine Dihydrochloride 7

Collapse (see also Cardio-vascular and Systemic disorders) Reaction Insights

323 reports name Collapse (see also Cardio-vascular and Systemic disorders); 120 recorded a death outcome (37.2% of reported events, not a population-level mortality rate). VeDDRA code: 668.

By species: Dog (277 reports), Cat (30 reports), Horse (13 reports). By breed: Crossbred Canine/dog (20), Retriever - Labrador (16), Terrier - Yorkshire (14).

Most co-reported drugs: Bedinvetmab (82 reports), Moxidectin (55 reports), Maropitant Citrate (30 reports), Pyrantel Pamoate;Sarolaner (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.