Reaction profile

The FDA adverse-event record for collapse nos (see also cardio-vascular and neurological disorders)

736 FDA adverse-event reports reference collapse nos (see also cardio-vascular and neurological disorders) (VeDDRA 1001). See the species, breeds, and drugs most associated with it below.

736
reports citing this reaction
36.8%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
736
Total Reports
271
Deaths
36.8%
Death Rate

Species Most Affected

Dog 634
Cat 76
Horse 16
Cattle 7
Goat 2
Rabbit 1

Breeds Most Affected

Retriever - Labrador 89
Domestic Shorthair 47
Retriever - Golden 39
Crossbred Canine/dog 34
Dog (unknown) 24
Shih Tzu 19
Shepherd Dog - German 18
Boxer (German Boxer) 17
Chihuahua 16
Shepherd Dog - Australian 16

Associated Drugs

Bedinvetmab 235
Gabapentin 92
Maropitant Citrate 59
Carprofen 48
Moxidectin 45
Trilostane 40
Afoxolaner 39
Pyrantel Pamoate;Sarolaner 38
Prednisone 33
Fluralaner 13.64% 12-Week Chew 28
Milbemycin Oxime + Praziquantel 26
Lotilaner 24
Grapiprant 22
Butorphanol 21
Pimobendan 20
Cefovecin 20
Frunevetmab 20
Metronidazole 20
Galliprant 19
Diphenhydramine 18

Collapse NOS (see also Cardio-vascular and Neurological disorders) Reaction Insights

736 reports name Collapse NOS (see also Cardio-vascular and Neurological disorders); 271 recorded a death outcome (36.8% of reported events, not a population-level mortality rate). VeDDRA code: 1001.

By species: Dog (634 reports), Cat (76 reports), Horse (16 reports). By breed: Retriever - Labrador (89), Domestic Shorthair (47), Retriever - Golden (39).

Most co-reported drugs: Bedinvetmab (235 reports), Gabapentin (92 reports), Maropitant Citrate (59 reports), Carprofen (48 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.