Reaction profile

The FDA adverse-event record for circling - neurological disorder (see also behavioural disorders)

433 FDA adverse-event reports reference circling - neurological disorder (see also behavioural disorders) (VeDDRA 652). See the species, breeds, and drugs most associated with it below.

433
reports citing this reaction
28.2%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
433
Total Reports
122
Deaths
28.2%
Death Rate

Species Most Affected

Dog 359
Cat 70
Horse 2
Rabbit 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 49
Retriever - Labrador 36
Crossbred Canine/dog 31
Bulldog - French 19
Chihuahua 18
Retriever - Golden 15
Terrier (unspecified) 14
Shih Tzu 12
Boxer (German Boxer) 12
Dog (unknown) 11

Associated Drugs

Bedinvetmab 135
Gabapentin 50
Pyrantel Pamoate;Sarolaner 41
Fluralaner 13.64% 12-Week Chew 34
Carprofen 30
Frunevetmab 27
Afoxolaner 26
Maropitant Citrate 20
Prednisone 19
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 17
Sarolaner 16
Oclacitinib Maleate 13
Trilostane 12
Anti-Il31 Mab Mcs Lot #1283563 11
Buprenorphine 9
Grapiprant 9
Midazolam 8
Cefovecin 8
Pimobendan 8
Maropitant 8

Circling - neurological disorder (see also Behavioural disorders) Reaction Insights

433 reports name Circling - neurological disorder (see also Behavioural disorders); 122 recorded a death outcome (28.2% of reported events, not a population-level mortality rate). VeDDRA code: 652.

By species: Dog (359 reports), Cat (70 reports), Horse (2 reports). By breed: Domestic Shorthair (49), Retriever - Labrador (36), Crossbred Canine/dog (31).

Most co-reported drugs: Bedinvetmab (135 reports), Gabapentin (50 reports), Pyrantel Pamoate;Sarolaner (41 reports), Fluralaner 13.64% 12-Week Chew (34 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.