Reaction profile

The FDA adverse-event record for circling - behavioural disorder (see also neurological disorders)

147 FDA adverse-event reports reference circling - behavioural disorder (see also neurological disorders) (VeDDRA 2611). See the species, breeds, and drugs most associated with it below.

147
reports citing this reaction
17.0%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
147
Total Reports
25
Deaths
17.0%
Death Rate

Species Most Affected

Dog 107
Cat 37
Cattle 2
Horse 1

Breeds Most Affected

Domestic Shorthair 19
Crossbred Canine/dog 12
Chihuahua 9
Shepherd Dog - German 7
Cat (unknown) 6
Retriever - Labrador 6
Shih Tzu 6
Terrier - Yorkshire 5
Retriever - Golden 4
Dog (unknown) 4

Associated Drugs

Bedinvetmab 37
Buprenorphine 27
Gabapentin 15
Lotilaner 10
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 9
Maropitant Citrate 9
Robenacoxib 9
Fluralaner 13.64% 12-Week Chew 8
Carprofen 7
Pyrantel Pamoate;Sarolaner 6
Dexmedetomidine 6
Anti-Il31 Mab Mcs Lot #1283563 5
Ketamine 5
Prednisone 5
Polysulfated Glycosaminoglycan 4
Frunevetmab 4
Milbemycin Oxime + Praziquantel 4
Alfaxalone 4
Mirtazapine 4
Antibiotic (Unknown) 3

Circling - behavioural disorder (see also Neurological disorders) Reaction Insights

147 reports name Circling - behavioural disorder (see also Neurological disorders); 25 recorded a death outcome (17.0% of reported events, not a population-level mortality rate). VeDDRA code: 2611.

By species: Dog (107 reports), Cat (37 reports), Cattle (2 reports). By breed: Domestic Shorthair (19), Crossbred Canine/dog (12), Chihuahua (9).

Most co-reported drugs: Bedinvetmab (37 reports), Buprenorphine (27 reports), Gabapentin (15 reports), Lotilaner (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.