Reaction profile

The FDA adverse-event record for chewing - pruritus (see also oral cavity disorders)

232 FDA adverse-event reports reference chewing - pruritus (see also oral cavity disorders) (VeDDRA 2618). See the species, breeds, and drugs most associated with it below.

232
reports citing this reaction
1.7%
death-coded share
Dog
most-affected species
Nitenpyram
most-associated drug
Verify with FDA CVM →
232
Total Reports
4
Deaths
1.7%
Death Rate

Species Most Affected

Dog 194
Cat 38

Breeds Most Affected

Domestic Shorthair 22
Retriever - Golden 22
Retriever - Labrador 15
Crossbred Canine/dog 14
Shepherd Dog - German 10
Chihuahua 10
Shih Tzu 9
Dog (unknown) 9
Collie - Border 7
Shepherd Dog - Australian 6

Associated Drugs

Nitenpyram 36
Lotilaner 24
Bedinvetmab 18
Oclacitinib Maleate 17
Milbemycin Oxime + Praziquantel 17
Afoxolaner 14
Gabapentin 12
Carprofen 11
Imidacloprid + Moxidectin 11
Fluralaner 13.64% 12-Week Chew 11
Imidacloprid, Flumethrin 10
Pyrantel Pamoate;Sarolaner 10
Milbemycin Oxime + Spinosad 9
Maropitant Citrate 7
Rabies Vaccine 7
Frunevetmab 6
Diphenhydramine 6
Ivermectin + Pyrantel As Pamoate Salt 6
Ilunocitinib 6
Anti-Il31 Mab Mcs Lot #1283563 6

Chewing - pruritus (see also Oral cavity disorders) Reaction Insights

232 reports name Chewing - pruritus (see also Oral cavity disorders); 4 recorded a death outcome (1.7% of reported events, not a population-level mortality rate). VeDDRA code: 2618.

By species: Dog (194 reports), Cat (38 reports). By breed: Domestic Shorthair (22), Retriever - Golden (22), Retriever - Labrador (15).

Most co-reported drugs: Nitenpyram (36 reports), Lotilaner (24 reports), Bedinvetmab (18 reports), Oclacitinib Maleate (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.