Reaction profile

The FDA adverse-event record for biting - pruritus (see also behavioural disorders)

205 FDA adverse-event reports reference biting - pruritus (see also behavioural disorders) (VeDDRA 2608). See the species, breeds, and drugs most associated with it below.

205
reports citing this reaction
1.5%
death-coded share
Dog
most-affected species
Nitenpyram
most-associated drug
Verify with FDA CVM →
205
Total Reports
3
Deaths
1.5%
Death Rate

Species Most Affected

Dog 129
Cat 75
Horse 1

Breeds Most Affected

Domestic Shorthair 47
Chihuahua 14
Retriever - Labrador 12
Dog (unknown) 10
Crossbred Canine/dog 9
Cat (unknown) 9
Domestic Longhair 9
Shih Tzu 6
Shepherd Dog - German 6
Retriever - Golden 6

Associated Drugs

Nitenpyram 61
Lotilaner 20
Afoxolaner 11
Fluralaner 13.64% 12-Week Chew 10
Imidacloprid + Permethrin + Pyriproxyfen 9
Frunevetmab 7
Pyrantel Pamoate;Sarolaner 7
Milbemycin Oxime + Praziquantel 7
Milbemycin Oxime + Spinosad 7
Fluralaner Spot-On Solution 6
Imidacloprid + Moxidectin 6
Fluralaner/Moxidectin Spot-On 6
Imidacloprid, Flumethrin 5
Imidacloprid 5
Diphenhydramine 5
Fluralaner 5.46% 1-Month Chew 5
Bedinvetmab 5
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 5
Selamectin 4
Oclacitinib Maleate 4

Biting - pruritus (see also Behavioural disorders) Reaction Insights

205 reports name Biting - pruritus (see also Behavioural disorders); 3 recorded a death outcome (1.5% of reported events, not a population-level mortality rate). VeDDRA code: 2608.

By species: Dog (129 reports), Cat (75 reports), Horse (1 reports). By breed: Domestic Shorthair (47), Chihuahua (14), Retriever - Labrador (12).

Most co-reported drugs: Nitenpyram (61 reports), Lotilaner (20 reports), Afoxolaner (11 reports), Fluralaner 13.64% 12-Week Chew (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.