Reaction profile

The FDA adverse-event record for biting -aggression (see also skin and appendages disorders)

197 FDA adverse-event reports reference biting -aggression (see also skin and appendages disorders) (VeDDRA 112). See the species, breeds, and drugs most associated with it below.

197
reports citing this reaction
13.7%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
197
Total Reports
27
Deaths
13.7%
Death Rate

Species Most Affected

Dog 148
Cat 45
Horse 3
Unknown 1

Breeds Most Affected

Domestic Shorthair 21
Crossbred Canine/dog 17
Retriever - Labrador 11
Shepherd Dog - German 9
Dog (unknown) 9
Chihuahua 8
Shih Tzu 7
Retriever - Golden 7
Poodle - Miniature 6
Domestic Longhair 6

Associated Drugs

Bedinvetmab 21
Gabapentin 17
Trilostane 14
Maropitant Citrate 14
Pyrantel Pamoate;Sarolaner 14
Oclacitinib Maleate 12
Insulin Injectable Vial 10
Buprenorphine 10
Fluralaner 13.64% 12-Week Chew 9
Frunevetmab 9
Carprofen 9
Prednisone 8
Lotilaner 8
Milbemycin Oxime + Praziquantel 8
Afoxolaner 6
Milbemycin Oxime 6
Robenacoxib 6
Cyclosporine 5
Cefovecin Sodium 5
Metronidazole 5

Biting -aggression (see also Skin and appendages disorders) Reaction Insights

197 reports name Biting -aggression (see also Skin and appendages disorders); 27 recorded a death outcome (13.7% of reported events, not a population-level mortality rate). VeDDRA code: 112.

By species: Dog (148 reports), Cat (45 reports), Horse (3 reports). By breed: Domestic Shorthair (21), Crossbred Canine/dog (17), Retriever - Labrador (11).

Most co-reported drugs: Bedinvetmab (21 reports), Gabapentin (17 reports), Trilostane (14 reports), Maropitant Citrate (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.