Drug profile

The FDA adverse-event record for Vitamin B-Complex

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Vitamin B-Complex. See the species affected, top reactions, and outcomes below.

31
adverse-event reports
71.0%
death-coded share
Dog
most-reported species
13
Anorexia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
22
Deaths Reported
71.0%
Death Rate

Active Ingredients

Vitamin B-Complex

Administration Routes

UnknownIntravenousSubcutaneous

Species Affected

Dog 15
Cat 15
Horse 1

Most Affected Breeds

Domestic Shorthair 11
Chihuahua 2
Boxer (German Boxer) 2
Terrier - Bull - American Pit 1
Maltese 1
Terrier (unspecified) 1
Retriever - Labrador 1
Terrier - Yorkshire 1
Domestic Longhair 1
Pinscher - Miniature 1

Most Reported Reactions

Anorexia 13
Lethargy (see also Central nervous system depression in 'Neurological') 12
Death 12
Vomiting 10
Other abnormal test result NOS 10
Death by euthanasia 10
Leucocytosis NOS 9
Elevated alanine aminotransferase (ALT) 8
Hyperphosphataemia 7
Anaemia NOS 6
Pale mucous membrane 6
Elevated serum alkaline phosphatase (SAP) 6

Outcome Breakdown

Died
13 (41.9%)
Euthanized
9 (29.0%)
Ongoing
7 (22.6%)
Recovered/Normal
1 (3.2%)
Outcome Unknown
1 (3.2%)

Vitamin B-Complex Adverse Event Insights

31 reports name Vitamin B-Complex; 22 recorded a death outcome (71.0% of reported events, not a population-level mortality rate). Active ingredient: Vitamin B-Complex. Administration routes: Unknown, Intravenous, Subcutaneous.

By species: Dog (15 reports), Cat (15 reports), Horse (1 reports). By breed: Domestic Shorthair (11), Chihuahua (2), Boxer (German Boxer) (2).

Leading clinical signs: Anorexia (13), Lethargy (see also Central nervous system depression in 'Neurological') (12), Death (12), Vomiting (10). Outcome, 31 coded reports: Died leads at 41.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.