Tramadol
3,623 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,623
Total Reports
622
Deaths Reported
1720.0%
Death Rate
Active Ingredients
Tramadol
Administration Routes
OralUnknownTransdermalOtherSubcutaneousOphthalmicTopicalOropharyngealParenteralIntravenous
Species Affected
Dog 3,581
Cat 27
Human 8
Unknown 2
Parrot 2
Other Canids 1
Other 1
Rabbit 1
Most Affected Breeds
Retriever - Labrador 717
Shepherd Dog - German 185
Crossbred Canine/dog 154
Retriever - Golden 153
Boxer (German Boxer) 112
Dog (unknown) 84
Chihuahua 80
Rottweiler 79
Shepherd Dog - Australian 73
Beagle 73
Most Reported Reactions
Vomiting 783
Lethargy (see also Central nervous system depression in 'Neurological') 682
Other abnormal test result NOS 507
Anorexia 454
Diarrhoea 444
Death by euthanasia 391
Elevated alanine aminotransferase (ALT) 335
Emesis 327
Lack of efficacy - NOS 298
Elevated serum alkaline phosphatase (SAP) 297
Weight loss 258
Decreased appetite 248
Outcome Breakdown
Ongoing
1,228 (34.0%)
Recovered/Normal
946 (26.2%)
Outcome Unknown
749 (20.7%)
Euthanized
396 (11.0%)
Died
226 (6.3%)
Recovered with Sequela
70 (1.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.