Drug profile

The FDA adverse-event record for Pantoprazole

349 FDA reports name Pantoprazole, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#383 of 2,679
by report volume (all drugs)
349
adverse-event reports
46.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Pantoprazole ranks #383 of 2679 by total reports (349) and #70 of 1130 by death-coded share (46.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#383
This drug, reports of 2679
#70
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Pantoprazole has 349 reports now versus 339 in that prior snapshot: 10 more (2.9%).

Report change
+10
Death-coded reports
+1
Death-coded share
−1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Pantoprazole changes

Signature read: death-coded report count at 161 is the most distinctive stamp on Pantoprazole's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
349
Total Reports
161
Deaths Reported
46.1%
Death-coded share of reports

Active Ingredients

Pantoprazole

Administration Routes

UnknownIntravenousOralParenteralSubcutaneousOther

Species Affected

Dog 298
Cat 38
Human 11
Alpaca 1
Other 1

Most Affected Breeds

Retriever - Labrador 53
Domestic Shorthair 14
Retriever - Golden 14
Unknown 13
Crossbred Canine/dog 13
Terrier - Yorkshire 11
Domestic Longhair 10
Chihuahua 9
Bulldog - French 9
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 9

Most Reported Reactions

Vomiting 129
Death by euthanasia 108
Other abnormal test result NOS 82
Lethargy (see also Central nervous system depression in 'Neurological') 81
Diarrhoea 78
Elevated alanine aminotransferase (ALT) 73
Anorexia 62
Elevated total bilirubin 62
Elevated blood urea nitrogen (BUN) 60
Abnormal radiograph finding 57
Leucocytosis NOS 54
Neutrophilia 52

Outcome Breakdown

Ongoing
106 (30.4%)
Euthanized
105 (30.1%)
Died
56 (16.0%)
Outcome Unknown
45 (12.9%)
Recovered/Normal
36 (10.3%)
Recovered with Sequela
1 (0.3%)

Pantoprazole: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Pantoprazole, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (46.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Pantoprazole (#383 of 2,679 by report volume); death-coded 46.1%. PlainBreed drug row · death-coded report count stamp 161 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →