Drug profile

The FDA adverse-event record for Pantoprazole

321 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Pantoprazole. See the species affected, top reactions, and outcomes below.

321
adverse-event reports
48.0%
death-coded share
Dog
most-reported species
117
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
321
Total Reports
154
Deaths Reported
48.0%
Death Rate

Active Ingredients

Pantoprazole

Administration Routes

UnknownIntravenousOralParenteralSubcutaneousOther

Species Affected

Dog 274
Cat 35
Human 10
Alpaca 1
Other 1

Most Affected Breeds

Retriever - Labrador 52
Retriever - Golden 14
Domestic Shorthair 13
Unknown 12
Terrier - Yorkshire 11
Crossbred Canine/dog 11
Chihuahua 9
Domestic Longhair 9
Bulldog - French 9
Poodle (unspecified) 8

Most Reported Reactions

Vomiting 117
Death by euthanasia 103
Lethargy (see also Central nervous system depression in 'Neurological') 81
Other abnormal test result NOS 80
Diarrhoea 69
Elevated alanine aminotransferase (ALT) 69
Anorexia 58
Elevated total bilirubin 55
Leucocytosis NOS 54
Elevated blood urea nitrogen (BUN) 54
Abnormal radiograph finding 49
Death 49

Outcome Breakdown

Euthanized
100 (31.2%)
Ongoing
90 (28.0%)
Died
54 (16.8%)
Outcome Unknown
43 (13.4%)
Recovered/Normal
33 (10.3%)
Recovered with Sequela
1 (0.3%)

Pantoprazole Adverse Event Insights

321 reports name Pantoprazole; 154 recorded a death outcome (48.0% of reported events, not a population-level mortality rate). Active ingredient: Pantoprazole. Administration routes: Unknown, Intravenous, Oral, Parenteral.

By species: Dog (274 reports), Cat (35 reports), Human (10 reports). By breed: Retriever - Labrador (52), Retriever - Golden (14), Domestic Shorthair (13).

Leading clinical signs: Vomiting (117), Death by euthanasia (103), Lethargy (see also Central nervous system depression in 'Neurological') (81), Other abnormal test result NOS (80). Outcome, 321 coded reports: Euthanized leads at 31.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.