Drug profile

The FDA adverse-event record for Methylprednisone Acetate

247 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Methylprednisone Acetate. See the species affected, top reactions, and outcomes below.

247
adverse-event reports
10.9%
death-coded share
Cat
most-reported species
77
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
247
Total Reports
27
Deaths Reported
10.9%
Death Rate

Active Ingredients

Methylprednisone Acetate

Administration Routes

UnknownParenteralSubcutaneousOralIntramuscular

Species Affected

Cat 137
Dog 110

Most Affected Breeds

Domestic Shorthair 90
Domestic Longhair 12
Crossbred Canine/dog 9
Domestic Mediumhair 9
Shih Tzu 8
Retriever - Labrador 8
Terrier - Yorkshire 7
Cat (unknown) 7
Chihuahua 7
Siamese 6

Most Reported Reactions

Emesis 77
Vomiting 54
Lethargy (see also Central nervous system depression in 'Neurological') 37
Lack of efficacy - NOS 22
Weight loss 19
Anorexia 18
Death 18
Behavioural disorder NOS 14
Diarrhoea 14
Seizure NOS 13
Other abnormal test result NOS 12
Lack of efficacy (ectoparasite) - flea 11

Outcome Breakdown

Recovered/Normal
121 (49.0%)
Outcome Unknown
52 (21.1%)
Ongoing
27 (10.9%)
Recovered with Sequela
20 (8.1%)
Died
20 (8.1%)
Euthanized
7 (2.8%)

Methylprednisone Acetate Adverse Event Insights

247 reports name Methylprednisone Acetate; 27 recorded a death outcome (10.9% of reported events, not a population-level mortality rate). Active ingredient: Methylprednisone Acetate. Administration routes: Unknown, Parenteral, Subcutaneous, Oral.

By species: Cat (137 reports), Dog (110 reports). By breed: Domestic Shorthair (90), Domestic Longhair (12), Crossbred Canine/dog (9).

Leading clinical signs: Emesis (77), Vomiting (54), Lethargy (see also Central nervous system depression in 'Neurological') (37), Lack of efficacy - NOS (22). Outcome, 247 coded reports: Recovered/Normal leads at 49.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.