Drug profile

The FDA adverse-event record for Lime Sulfur

15 FDA reports name Lime Sulfur, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2107 of 2,679
by report volume (all drugs)
15
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Lime Sulfur ranks #2072 of 2679 by total reports (15). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2072
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lime Sulfur has 15 reports now versus 15 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lime Sulfur changes

Signature read: 15 reports place Lime Sulfur in the lower third of FDA AER volume (#2107 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
2
Deaths Reported
13.3%
Death-coded share of reports

Active Ingredients

Lime Sulfur

Administration Routes

TopicalUnknown

Species Affected

Dog 8
Cat 7

Most Affected Breeds

Domestic Shorthair 5
Deutsche Dogge, Great Dane 1
Spaniel - Boykin 1
Cat (other) 1
Terrier - Bull - American Pit 1
Chihuahua 1
Bulldog 1
Domestic Longhair 1
Shih Tzu 1
Pug 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 6
Lack of efficacy - NOS 3
Emesis 2
Application site pruritus 2
Not eating 2
Death by euthanasia 2
Seizure NOS 2
Diarrhoea 1
Vomiting 1
Uveitis 1
Conjunctivitis 1
Overdose 1

Outcome Breakdown

Ongoing
9 (60.0%)
Recovered/Normal
2 (13.3%)
Outcome Unknown
2 (13.3%)
Euthanized
2 (13.3%)

Lime Sulfur: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lime Sulfur (#2107 of 2,679 by report volume); death-coded 13.3%. PlainBreed drug row · report volume stamp 15 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →