Drug profile

The FDA adverse-event record for Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg

1,397 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg. See the species affected, top reactions, and outcomes below.

1,397
adverse-event reports
0.7%
death-coded share
Dog
most-reported species
709
INEFFECTIVE, HEARTWORM LARVAE - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,397
Total Reports
10
Deaths Reported
0.7%
Death Rate

Active Ingredients

Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg

Administration Routes

OralUnknown

Species Affected

Dog 1,293
Unknown 104

Most Affected Breeds

Retriever - Labrador 404
Crossbred Canine/dog 167
Retriever - Golden 111
Unknown 104
Shepherd Dog - German 96
Boxer (German Boxer) 47
Dog (other) 35
Pit Bull 33
Dog (unknown) 27
Rottweiler 26

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 709
Digestive tract disorder NOS 503
Cardiac disorder NOS 441
No sign 237
INEFFECTIVE, ASCARIDS NOS 232
Lack of efficacy (endoparasite) - hookworm 231
Lack of efficacy - NOS 122
Vomiting 69
Tablets, Abnormal 57
Diarrhoea 33
INEFFECTIVE, HEARTWORM ADULTS 28
Lethargy (see also Central nervous system depression in 'Neurological') 26

Outcome Breakdown

Outcome Unknown
749 (57.5%)
Recovered with Sequela
467 (35.8%)
Recovered/Normal
60 (4.6%)
Ongoing
17 (1.3%)
Died
6 (0.5%)
Euthanized
4 (0.3%)

Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg Adverse Event Insights

1,397 reports name Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg; 10 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg. Administration routes: Oral, Unknown.

By species: Dog (1,293 reports), Unknown (104 reports). By breed: Retriever - Labrador (404), Crossbred Canine/dog (167), Retriever - Golden (111).

Leading clinical signs: INEFFECTIVE, HEARTWORM LARVAE (709), Digestive tract disorder NOS (503), Cardiac disorder NOS (441), No sign (237). Outcome, 1,303 coded reports: Outcome Unknown leads at 57.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.