Ivermectin/Pyrantel
1,031 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,031
Total Reports
37
Deaths Reported
360.0%
Death Rate
Active Ingredients
Ivermectin/Pyrantel
Administration Routes
OralUnknownTopical
Species Affected
Dog 1,028
Unknown 3
Most Affected Breeds
Retriever - Labrador 169
Crossbred Canine/dog 96
Shepherd Dog - German 62
Retriever - Golden 38
Chihuahua 29
Terrier - Bull - American Pit 29
Boxer (German Boxer) 28
Terrier (unspecified) 28
Shih Tzu 25
Dog (unknown) 24
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 281
INEFFECTIVE, HEARTWORM LARVAE 178
Vomiting 149
Lethargy (see also Central nervous system depression in 'Neurological') 86
Diarrhoea 74
Seizure NOS 59
Lack of efficacy - NOS 38
Anorexia 33
Weight loss 31
Lack of efficacy (heartworm) 31
Emesis 30
Decreased appetite 29
Outcome Breakdown
Outcome Unknown
409 (39.8%)
Ongoing
351 (34.1%)
Recovered/Normal
226 (22.0%)
Euthanized
26 (2.5%)
Died
11 (1.1%)
Recovered with Sequela
5 (0.5%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.