Ivermectin(1%)/Clorsulon(10%) Injection

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304 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
304
Total Reports
24
Deaths Reported
790.0%
Death Rate

Active Ingredients

Ivermectin(1%)/Clorsulon(10%) Injection

Administration Routes

UnknownSubcutaneousOralIntramuscularIntradermalOphthalmicTopicalParenteral

Species Affected

Unknown 200
Cattle 69
Dog 20
Human 8
Horse 3
Cat 1
Other Birds 1
Sheep 1
Hedgehog 1

Most Affected Breeds

Unknown 212
Cattle (unknown) 24
Crossbred Bovine/Cattle 11
Cattle (other) 9
Aberdeen Angus 8
Holstein-Friesian also known as Holstein 5
Retriever - Labrador 4
Standardbred (unspecified) 3
Dog (unknown) 3
Collie - Border 2

Most Reported Reactions

Uncoded sign 123
Caps, Abnormal 98
Stopper, abnormal 54
Closure, Abnormal 20
Death 17
Ataxia 11
Systemic disorder NOS 11
Digestive tract disorder NOS 9
Vomiting 8
Mydriasis 8
Seal, Abnormal 7
Lack of efficacy (endoparasite) - trematode 7

Outcome Breakdown

Outcome Unknown
69 (59.5%)
Died
20 (17.2%)
Recovered/Normal
15 (12.9%)
Ongoing
7 (6.0%)
Euthanized
5 (4.3%)

Data Summary

Metric Value
Total adverse event reports 304
Reports involving death 24
Case-fatality rate (reported events) 790.0%
Distinct species in reports 9
Distinct breeds in reports 20
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Ivermectin(1%)/Clorsulon(10%) Injection Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 304 adverse event reports referencing Ivermectin(1%)/Clorsulon(10%) Injection, including 24 reports in which the animal died — a 790.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Ivermectin(1%)/Clorsulon(10%) Injection. Reported administration routes include Unknown, Subcutaneous, Oral, Intramuscular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Ivermectin(1%)/Clorsulon(10%) Injection reports are Unknown (200 reports), Cattle (69 reports), Dog (20 reports), with Unknown accounting for the largest share. Within those species, Unknown (212), Cattle (unknown) (24), Crossbred Bovine/Cattle (11) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Ivermectin(1%)/Clorsulon(10%) Injection are Uncoded sign (123), Caps, Abnormal (98), Stopper, abnormal (54), Closure, Abnormal (20). Of the 116 reports with a coded outcome, Outcome Unknown is the leading category at 59.5%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Ivermectin(1%)/Clorsulon(10%) Injection.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial