Ivermectin + Pyrantel Pamoate
2,818 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,818
Total Reports
68
Deaths Reported
240.0%
Death Rate
Active Ingredients
IvermectinIvermectin + Pyrantel PamoatePyrantel Pamoate
Administration Routes
OralUnknownTopicalOphthalmicIntrauterine
Species Affected
Dog 2,759
Unknown 56
Human 3
Most Affected Breeds
Retriever - Labrador 374
Shepherd Dog - German 161
Crossbred Canine/dog 126
Chihuahua 119
Terrier - Yorkshire 99
Pit Bull 95
Dog (unknown) 87
Retriever - Golden 84
Shih Tzu 83
Boxer (German Boxer) 73
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 789
Emesis 577
Vomiting 390
Lethargy (see also Central nervous system depression in 'Neurological') 224
Lack of efficacy (ectoparasite) - flea 155
Diarrhoea 136
Seizure NOS 93
INEFFECTIVE, HEARTWORM LARVAE 87
Other abnormal test result NOS 74
Not eating 70
Lack of efficacy - NOS 70
Behavioural disorder NOS 65
Outcome Breakdown
Outcome Unknown
1,281 (46.4%)
Recovered/Normal
1,090 (39.4%)
Ongoing
191 (6.9%)
Recovered with Sequela
133 (4.8%)
Died
35 (1.3%)
Euthanized
33 (1.2%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.