Drug profile

The FDA adverse-event record for Interceptor

217 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Interceptor. See the species affected, top reactions, and outcomes below.

217
adverse-event reports
6.5%
death-coded share
Dog
most-reported species
85
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
217
Total Reports
14
Deaths Reported
6.5%
Death Rate

Active Ingredients

Interceptor

Administration Routes

OralUnknown

Species Affected

Dog 217

Most Affected Breeds

Retriever - Labrador 35
Crossbred Canine/dog 18
Retriever - Golden 12
Terrier - Bull - American Pit 11
Dog (unknown) 9
Shepherd Dog - German 9
Pit Bull 6
Boxer (German Boxer) 6
Chihuahua 6
Bulldog - French 5

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 85
Vomiting 36
Seizure NOS 22
Diarrhoea 13
Not eating 12
Emesis (multiple) 9
Death 7
Death by euthanasia 7
Ataxia 7
Panting 6
Behavioural disorder NOS 6
Lethargy (see also Central nervous system depression in 'Neurological') 6

Outcome Breakdown

Ongoing
120 (54.8%)
Recovered/Normal
49 (22.4%)
Outcome Unknown
36 (16.4%)
Died
7 (3.2%)
Euthanized
7 (3.2%)

Interceptor Adverse Event Insights

217 reports name Interceptor; 14 recorded a death outcome (6.5% of reported events, not a population-level mortality rate). Active ingredient: Interceptor. Administration routes: Oral, Unknown.

By species: Dog (217 reports). By breed: Retriever - Labrador (35), Crossbred Canine/dog (18), Retriever - Golden (12).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (85), Vomiting (36), Seizure NOS (22), Diarrhoea (13). Outcome, 219 coded reports: Ongoing leads at 54.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.