Drug profile

The FDA adverse-event record for Interceptor

222 FDA reports name Interceptor, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#517 of 2,679
by report volume (all drugs)
222
adverse-event reports
6.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Interceptor ranks #515 of 2679 by total reports (222) and #725 of 1130 by death-coded share (6.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#515
This drug, reports of 2679
#725
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Interceptor has 222 reports now versus 219 in that prior snapshot: 3 more (1.4%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Interceptor changes

Signature read: 222 reports place Interceptor in the upper third of FDA AER volume (#517 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
222
Total Reports
14
Deaths Reported
6.3%
Death-coded share of reports

Active Ingredients

Interceptor

Administration Routes

OralUnknown

Species Affected

Dog 222

Most Affected Breeds

Retriever - Labrador 37
Crossbred Canine/dog 18
Retriever - Golden 12
Terrier - Bull - American Pit 12
Dog (unknown) 9
Shepherd Dog - German 9
Pit Bull 6
Boxer (German Boxer) 6
Chihuahua 6
Bulldog - French 5

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 88
Vomiting 36
Seizure NOS 22
Diarrhoea 13
Not eating 12
Emesis (multiple) 9
Death by euthanasia 7
Death 7
Ataxia 7
Lack of efficacy (endoparasite) - hookworm 6
Lethargy (see also Central nervous system depression in 'Neurological') 6
Panting 6

Outcome Breakdown

Ongoing
125 (55.8%)
Recovered/Normal
49 (21.9%)
Outcome Unknown
36 (16.1%)
Euthanized
7 (3.1%)
Died
7 (3.1%)

Interceptor: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Interceptor, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Interceptor (#517 of 2,679 by report volume); death-coded 6.3%. PlainBreed drug row · report volume stamp 222 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →