Drug profile

The FDA adverse-event record for Herbals

43 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Herbals. Species, reactions, and outcomes follow.

#1219 of 2,679
by report volume (all drugs)
43
adverse-event reports
4.7%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Herbals ranks #1213 of 2679 by total reports (43). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1213
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Herbals has 43 reports now versus 43 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Herbals changes

Signature read: Herbals's 4.7% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
43
Total Reports
2
Deaths Reported
4.7%
Death-coded share of reports

Active Ingredients

Herbals

Administration Routes

OralUnknownTopical

Species Affected

Dog 38
Cat 5

Most Affected Breeds

Retriever - Labrador 5
Domestic Shorthair 3
Shepherd Dog - German 3
Rottweiler 2
Chihuahua 2
Boxer (German Boxer) 2
Poodle (unspecified) 2
Mastiff 2
Pit Bull 2
Dog (unknown) 2

Most Reported Reactions

Emesis 16
Behavioural disorder NOS 6
Lethargy (see also Central nervous system depression in 'Neurological') 5
Vomiting 4
Lack of efficacy (ectoparasite) - flea 4
Ataxia 4
Diarrhoea 3
Adrenal gland disorder NOS 3
Panting 3
Anorexia 3
Seizure NOS 3
Elevated creatinine 3

Outcome Breakdown

Recovered/Normal
21 (48.8%)
Outcome Unknown
10 (23.3%)
Recovered with Sequela
5 (11.6%)
Ongoing
5 (11.6%)
Euthanized
1 (2.3%)
Died
1 (2.3%)

Herbals: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Herbals (#1219 of 2,679 by report volume); death-coded 4.7%. PlainBreed drug row · death-coded share stamp 4.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →