Drug profile

The FDA adverse-event record for Enema

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Enema. Species, reactions, and outcomes follow.

#1423 of 2,679
by report volume (all drugs)
31
adverse-event reports
32.3%
death-coded share
Cat
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Enema ranks #1412 of 2679 by total reports (31). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Enema has 31 reports now versus 30 in that prior snapshot: 1 more (3.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Enema changes

Signature read: Enema's 32.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
10
Deaths Reported
32.3%
Death-coded share of reports

Active Ingredients

Enema

Administration Routes

RectalOtherUnknown

Species Affected

Cat 27
Dog 4

Most Affected Breeds

Domestic Shorthair 19
Persian 2
Domestic Mediumhair 1
Cat (unknown) 1
Doberman Pinscher 1
Terrier - Jack Russell 1
Domestic Longhair 1
Burmese 1
Domestic (unspecified) 1
Great Pyrenees 1

Most Reported Reactions

Constipation 12
Lethargy (see also Central nervous system depression in 'Neurological') 9
Weight loss 8
Death by euthanasia 8
Vomiting 7
Anorexia 6
Behavioural disorder NOS 5
Dehydration 5
Other abnormal test result NOS 4
Abnormal radiograph finding 4
Elevated blood urea nitrogen (BUN) 4
Hyperglycaemia 4

Outcome Breakdown

Outcome Unknown
9 (29.0%)
Euthanized
8 (25.8%)
Ongoing
6 (19.4%)
Recovered/Normal
5 (16.1%)
Died
2 (6.5%)
Recovered with Sequela
1 (3.2%)

Enema: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Enema (#1423 of 2,679 by report volume); death-coded 32.3%. PlainBreed drug row · death-coded share stamp 32.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →