Drug profile

The FDA adverse-event record for Enema

30 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Enema. See the species affected, top reactions, and outcomes below.

30
adverse-event reports
33.3%
death-coded share
Cat
most-reported species
11
Constipation - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
30
Total Reports
10
Deaths Reported
33.3%
Death Rate

Active Ingredients

Enema

Administration Routes

RectalOtherUnknown

Species Affected

Cat 26
Dog 4

Most Affected Breeds

Domestic Shorthair 18
Persian 2
Domestic Mediumhair 1
Cat (unknown) 1
Doberman Pinscher 1
Terrier - Jack Russell 1
Domestic Longhair 1
Burmese 1
Domestic (unspecified) 1
Great Pyrenees 1

Most Reported Reactions

Constipation 11
Lethargy (see also Central nervous system depression in 'Neurological') 9
Weight loss 8
Death by euthanasia 8
Vomiting 7
Anorexia 6
Behavioural disorder NOS 5
Dehydration 5
Other abnormal test result NOS 4
Abnormal radiograph finding 4
Elevated blood urea nitrogen (BUN) 4
Hyperglycaemia 4

Outcome Breakdown

Outcome Unknown
9 (30.0%)
Euthanized
8 (26.7%)
Recovered/Normal
5 (16.7%)
Ongoing
5 (16.7%)
Died
2 (6.7%)
Recovered with Sequela
1 (3.3%)

Enema Adverse Event Insights

30 reports name Enema; 10 recorded a death outcome (33.3% of reported events, not a population-level mortality rate). Active ingredient: Enema. Administration routes: Rectal, Other, Unknown.

By species: Cat (26 reports), Dog (4 reports). By breed: Domestic Shorthair (18), Persian (2), Domestic Mediumhair (1).

Leading clinical signs: Constipation (11), Lethargy (see also Central nervous system depression in 'Neurological') (9), Weight loss (8), Death by euthanasia (8). Outcome, 30 coded reports: Outcome Unknown leads at 30.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.